Micky van de Ven Double Ends The Toffees' Unbeaten Streak at Brand New Stadium
The Dutch defender emerged as the initial defender to score two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads home twice in opening period
Everton's Jake O'Brien has equalizer disallowed after VAR review
Senegalese midfielder scores third in dying moments
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Tottenham extended their unbeaten run in away games in the top division and handed the Toffees their first defeat at their new home.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after more than a century at the end of the previous campaign.
But Spurs captain the Dutchman pounced twice from corners in the first half to place their strong form at risk, and they were unable to turn it around before the midfielder - set up by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
The Everton defender thought he had equalized the scores five minutes after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a handful of opportunities, while Vicario made a series of fine saves to ensure Tottenham went five away games without defeat in the English top flight.
But the VAR stepped in, advising Craig Pawson to review the score on the pitchside monitor and the official decided that Jack Grealish and the attacker were in offside positions and had impeded with the Spurs keeper.
The win moves the manager's side into third place in the division, a handful of points off north London rivals and table-toppers Arsenal.
Everton remain 14th and are half a dozen points ahead of the drop zone.
Tottenham analysis: The defender fulfils role at each end of pitch
After a uninspiring weekday performance in the European competition against the French side, where they managed a mere two shots on goal, Frank chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being replaced for the substitute after an hour on the pitch, but it emerged he proved unnecessary in the end.
Centre-back Van de Ven converted into an attacking force to be feared.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked Van de Ven to score.
And the captain - filling in as skipper in the Argentine's absence - added his second in first-half stoppage time as he rose above Jordan Pickford to head home.
Van de Ven was just as outstanding in defensive duties, partnering well with his defensive colleague as the pair handled superbly with the 34 crosses sent their way by the opposition.
Everton analysis: Toffees lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the novelty may have faded somewhat and fans headed to the gates after Sarr's third for Tottenham.
The break in the team's unbeaten home run will not be a major concern for the manager, but their striker situation are.
The forward and Thierno Barry - the Everton's pair of recognised strikers - had netted just a single goal combined before the weekend's outing.
And they were unable to add to that miserable tally on a damp and dreary night on in Liverpool.
The striker's performance was summed up when he chose to overhead kick a clear chance from close range, even with having space and opportunity to readjust for a simpler attempt that would have challenged the keeper.
The substitute, as well, was unable to make an impact after replacing Beto in the second half.
It was not for a shortage of chance. The majority of the home side's attacks came through Grealish and Ndiaye, who relentlessly delivered threatening balls into the Spurs box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: The London club travel to St James' Park on late October for their next round League Cup match against the Magpies.